Thymus Transcriptome and Cell Biology

· Springer
E-kitap
318
Sayfa
Puanlar ve yorumlar doğrulanmaz Daha Fazla Bilgi

Bu e-kitap hakkında

This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity.

The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.

Yazar hakkında

Geraldo Aleixo Passos received his PhD degree in biochemistry (1988) from Ribeirão Preto Medical School, University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS), France (1992-94) with sequencing and physical mapping of the human immunoglobulin lambda locus on chromosome 22q11.2. During several years he worked in close collaboration in the microarray laboratory at Centre d ́Immunologie de Marseille-Luminy (CIML, Marseille, France) (1999-2001) and then in the Unité INSERM 1090 in Marseille (2002-17) to study the large-scale gene expression in the thymus. He is currently Associate Professor (Genetics and Molecular Biology) at School of Dentistry and Ribeirão Preto Medical School (USP, Campus of Ribeirão Preto, Brazil). He is the coordinator of the Molecular Immunogenetics Group. He was the adviser of two PhD theses awarded by Ministry of Education/CAPES: in 2008, one of his students received theCAPES Thesis Award and in 2010, another student received the distinction CAPES Thesis Honor in Genetics.

Bu e-kitaba puan verin

Düşüncelerinizi bizimle paylaşın.

Okuma bilgileri

Akıllı telefonlar ve tabletler
Android ve iPad/iPhone için Google Play Kitaplar uygulamasını yükleyin. Bu uygulama, hesabınızla otomatik olarak senkronize olur ve nerede olursanız olun çevrimiçi veya çevrimdışı olarak okumanıza olanak sağlar.
Dizüstü bilgisayarlar ve masaüstü bilgisayarlar
Bilgisayarınızın web tarayıcısını kullanarak Google Play'de satın alınan sesli kitapları dinleyebilirsiniz.
e-Okuyucular ve diğer cihazlar
Kobo eReader gibi e-mürekkep cihazlarında okumak için dosyayı indirip cihazınıza aktarmanız gerekir. Dosyaları desteklenen e-kitap okuyuculara aktarmak için lütfen ayrıntılı Yardım Merkezi talimatlarını uygulayın.