Thymus Transcriptome and Cell Biology

· Springer
E‑kniha
318
Počet strán
Hodnotenia a recenzie nie sú overené  Ďalšie informácie

Táto e‑kniha

This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity.

The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.

O autorovi

Geraldo Aleixo Passos received his PhD degree in biochemistry (1988) from Ribeirão Preto Medical School, University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS), France (1992-94) with sequencing and physical mapping of the human immunoglobulin lambda locus on chromosome 22q11.2. During several years he worked in close collaboration in the microarray laboratory at Centre d ́Immunologie de Marseille-Luminy (CIML, Marseille, France) (1999-2001) and then in the Unité INSERM 1090 in Marseille (2002-17) to study the large-scale gene expression in the thymus. He is currently Associate Professor (Genetics and Molecular Biology) at School of Dentistry and Ribeirão Preto Medical School (USP, Campus of Ribeirão Preto, Brazil). He is the coordinator of the Molecular Immunogenetics Group. He was the adviser of two PhD theses awarded by Ministry of Education/CAPES: in 2008, one of his students received theCAPES Thesis Award and in 2010, another student received the distinction CAPES Thesis Honor in Genetics.

Ohodnoťte túto elektronickú knihu

Povedzte nám svoj názor.

Informácie o dostupnosti

Smartfóny a tablety
Nainštalujte si aplikáciu Knihy Google Play pre AndroidiPad/iPhone. Automaticky sa synchronizuje s vaším účtom a umožňuje čítať online aj offline, nech už ste kdekoľvek.
Laptopy a počítače
Audioknihy zakúpené v službe Google Play môžete počúvať prostredníctvom webového prehliadača v počítači.
Čítačky elektronických kníh a ďalšie zariadenia
Ak chcete tento obsah čítať v zariadeniach využívajúcich elektronický atrament, ako sú čítačky e‑kníh Kobo, musíte stiahnuť príslušný súbor a preniesť ho do svojho zariadenia. Pri prenose súborov do podporovaných čítačiek e‑kníh postupujte podľa podrobných pokynov v centre pomoci.