Somatic Diversification of Immune Responses

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· Current Topics in Microbiology and Immunology 229. књига · Springer Science & Business Media
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Π‘Ρ‚Ρ€Π°Π½ΠΈΡ†Π°
ΠžΡ†Π΅Π½Π΅ ΠΈ Ρ€Π΅Ρ†Π΅Π½Π·ΠΈΡ˜Π΅ нису Π²Π΅Ρ€ΠΈΡ„ΠΈΠΊΠΎΠ²Π°Π½Π΅ Β Π‘Π°Π·Π½Π°Ρ˜Ρ‚Π΅ вишС

О овој С-књизи

Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.

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ΠœΠΎΠΆΠ΅Ρ‚Π΅ Π΄Π° ΡΠ»ΡƒΡˆΠ°Ρ‚Π΅ Π°ΡƒΠ΄ΠΈΠΎ-књигС ΠΊΡƒΠΏΡ™Π΅Π½Π΅ Π½Π° Google Play-Ρƒ ΠΏΠΎΠΌΠΎΡ›Ρƒ Π²Π΅Π±-ΠΏΡ€Π΅Π³Π»Π΅Π΄Π°Ρ‡Π° Π½Π° Ρ€Π°Ρ‡ΡƒΠ½Π°Ρ€Ρƒ.
Π•-Ρ‡ΠΈΡ‚Π°Ρ‡ΠΈ ΠΈ Π΄Ρ€ΡƒΠ³ΠΈ ΡƒΡ€Π΅Ρ’Π°Ρ˜ΠΈ
Π”Π° бистС Ρ‡ΠΈΡ‚Π°Π»ΠΈ Π½Π° ΡƒΡ€Π΅Ρ’Π°Ρ˜ΠΈΠΌΠ° којС користС Π΅-мастило, ΠΊΠ°ΠΎ ΡˆΡ‚ΠΎ су Kobo Π΅-Ρ‡ΠΈΡ‚Π°Ρ‡ΠΈ, Ρ‚Ρ€Π΅Π±Π° Π΄Π° ΠΏΡ€Π΅ΡƒΠ·ΠΌΠ΅Ρ‚Π΅ Ρ„Π°Ρ˜Π» ΠΈ прСнСсСтС Π³Π° Π½Π° ΡƒΡ€Π΅Ρ’Π°Ρ˜. ΠŸΡ€Π°Ρ‚ΠΈΡ‚Π΅ Π΄Π΅Ρ‚Π°Ρ™Π½Π° упутства ΠΈΠ· Ρ†Π΅Π½Ρ‚Ρ€Π° Π·Π° ΠΏΠΎΠΌΠΎΡ› Π΄Π° бистС ΠΏΡ€Π΅Π½Π΅Π»ΠΈ Ρ„Π°Ρ˜Π»ΠΎΠ²Π΅ Ρƒ ΠΏΠΎΠ΄Ρ€ΠΆΠ°Π½Π΅ Π΅-Ρ‡ΠΈΡ‚Π°Ρ‡Π΅.