Legionella Pneumophila: Pathogenesis and Immunity
Paul Hoffman · Herman Friedman · Mauro Bendinelli
okt 2007 · Springer Science & Business Media
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208
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Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been new developments in this field including the publication of three whole genome sequences, the discovery of a developmental cycle and novel cyst-like highly infectious form, and the bacteria have been used as a probe for macrophage cellular function to unravel fundamental new knowledge in the area of cellular biology. Legionella has also become a model system for the study of innate as well as adaptive immunity. Information on Legionella continues to increase in the U.S. and abroad. Columbia University has started the first Legionella Genome Project with a multi-million dollar grant from the NIH. In addition, The European Working Group for Legionella infections was formed in 1986. Members are scientists with an interest in improving knowledge and information on the clinical and environmental aspects of legionnaires' disease through developments in diagnosis, management and treatment of the disease. The volume brings together all of the lastest research on this pathogen, the interest in which is rapidly growing.
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Paul Hoffman is an American intellectual who has devoted much of his professional life to making the work of serious scholars available to the general public. Hoffman has served as editor of Discover magazine and publisher of Encyclopaedia Brittanica. He has also contributed to such television programs as CBS Sunday Morning and PBS' News Hour with Jim Lehrer. Hoffman's books include Archimedes' Revenge and The Man who Loved Only Numbers, a popular biography of the mathematician Paul Erdos.
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